|
Ventricular arrhythmia
|
|
0.010 |
GeneticVariation
|
BEFREE |
beta1AR (Ser49Gly, Arg389Gly) and beta2AR (Gly16Arg, Gln27Glu) SNPs were genotyped in a case-control study comparing 107 patients with CAD and aborted SCD due to VA with 287 CAD control subjects and 101 healthy control subjects.
|
18534365 |
2008 |
|
Tuberculosis, Pulmonary
|
|
0.010 |
GeneticVariation
|
BEFREE |
Genotype distributions of the rs1042713 (Arg16Gly +46A>G) and rs1042714 (Gln27Glu +79C>G) polymorphisms in ADRB2 gene in 106 patients with pulmonary tuberculosis and 88 healthy subjects were studied by PCR-RFLP method in an Iranian population.
|
27900465 |
2017 |
|
Tuberculosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The association was reported between rs1042713 and rs1042714 polymorphisms in ADRB2 gene and tuberculosis for the first time. rs1042713*G and rs1042714*G polymorphisms in ADRB2 gene makes people more susceptible to develop the disease.
|
27900465 |
2017 |
|
Steatohepatitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Univariate analysis indicated that subjects with the heterozygous Gln27Glu mutant alleles had a significantly higher prevalence of fatty liver vs. those without the mutation (Glu27 allele frequency, 0.07 vs. 0.12, p=0.047; odds ratio, 1.92; 95% confidence interval, 1.01-3.68).
|
11718682 |
2001 |
|
ST segment elevation myocardial infarction
|
|
0.010 |
GeneticVariation
|
BEFREE |
For the ADRB2 Gln27Glu polymorphism, subjects having one or two copies of the Glu27 allele showed a decreased risk of MI compared with Gln27 homozygote subjects (OR=0.48, 95% CI=0.24-0.94, P=0.03).
|
19623647 |
2009 |
|
Primary congenital glaucoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
These results suggest no evidence of an association between the Arg16Gly, Glu27Gln and Thr164Ile polymorphisms of the B2AR gene and risk of developing primary open angle glaucoma or primary congenital glaucoma.
|
13680034 |
2003 |
|
Polycystic Ovary Syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
ADRB2 haplotypes (comprising rs1042711, rs1801704, rs1042713 and rs1042714 in that order), genotyping and statistical analysis to evaluate associations with continuous variables and traits related to IR and MS in a PCOS population.
|
22900502 |
2013 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Obesity risk is associated with carbohydrate intake in women carrying the Gln27Glu beta2-adrenoceptor polymorphism.
|
12888635 |
2003 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
We evaluated Gln27Glu polymorphism in the β2AR gene in obese Saudi populations to investigate the association of β2AR gene with obesity</span> and other related metabolic parameters.
|
20738880 |
2010 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
The Gln27Glu polymorphism was markedly associated with obesity with a relative risk for obesity of approximately 7 and an odds ratio of approximately 10.
|
9399946 |
1997 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our study indicates that the ADRB2 rs1042714 SNP may contribute to the risk of obesity and predict obesity-related metabolic traits such as BMI, triglyceride, and systolic blood pressure in Taiwanese subjects.
|
24322328 |
2014 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
The summary odds ratio (OR) from overall analyses showed no association between either rs1042714 or rs1042713 and obesity.
|
19186333 |
2008 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our results suggest that the Gln27Glu and Arg16Gly polymorphisms of the beta2AR gene are not a major contributing factor to obesity in Japanese men.
|
11016907 |
2000 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Additionally, for the polymorphic sites of BAR-2 (Arg16Gly and Gln27Glu) a significant effect on obesity risk was seen.
|
12395215 |
2002 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Interactions were detected between ADRA2A C-1291G and ADRB2 Gln27-->Glu variants for obesity in African Americans and between ADRA2A C-1291G SNP and ADBR1 haplotype for obesity in whites.
|
17512307 |
2007 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our meta-analysis revealed that the rs1042714 (Gln27Glu) polymorphism is associated with obesity susceptibility.
|
24960039 |
2014 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Even in Japanese-Americans, who have a more westernized life style than Japanese, the association of the beta(2)-AR gene (Gln27Glu) variant with the parameters of obesity, insulin resistance, and serum lipid level has yet to be clarified.
|
11288039 |
2001 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
As there is a high prevalence of obesity in Tonga, we aimed to determine the distribution of the beta2 adrenoceptor gene Gln(27)Glu polymorphism and to assess its relevance to obesity and to Type II diabetes, known to be prevalent in that population.
|
12605574 |
2003 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
A total of 107 unrelated overweight/obese individuals were genotyped for two ADRB2 non-synonymous polymorphisms: Arg16Gly (rs1042713) and Gln27Glu (rs1042714).
|
29331538 |
2018 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Gender is an effect modifier for the effect of the rs1042714 polymorphism on obesity-related traits in Malaysian Malays.
|
22199155 |
2015 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
These results provide evidence about a possible impact of the Gln27Glu polymorphism in the ADRB2 gene concerning a better response to exercise in obese Gln27 female subjects, in which basal insulinemia may play a role.
|
12435085 |
2002 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
The different effects of a Gln27Glu beta 2-adrenoceptor gene polymorphism on obesity in males and in females.
|
10205587 |
1999 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
In summary, we have found that in Japanese men the Gln27Glu beta2AR variant is associated with obesity due to subcutaneous fat accumulation.
|
10222249 |
1999 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Several case-control studies have explored the possible association between polymorphism in the beta2 adrenoreceptor gene (beta2AR), hypertension, and obesity--the focus being in particular on the Arg16Gly and Gln27Glu substitutions, which appear to modify the extracellular part of the beta2AR with possible functional modification.
|
15323067 |
2004 |
|
Myocardial Infarction
|
|
0.050 |
GeneticVariation
|
BEFREE |
Four ADRB2 gene polymorphisms C19R (T-47C), T-20C, G16R (G+46A), Q27E (C+79G) were investigated in two studies: PEGASE, a study of moderate to severe hypertension (707 cases) conducted in France, and ECTIM, a case-control study of MI (1178 cases, 1187 controls) conducted in France, Northern Ireland and Scotland.
|
11821707 |
2002 |